Invitro and Invivo Antiasthmatic Activity of Ethanolic Bark Extract of Symplocos Racemosa

The aim of the present study was to evaluate invitro and invivo antiasthmatic activity of ethanolic bark extract of Symplocos racemosa. For invitro study, isolated guinea pig ileum was used and dose response curve of histamine in plain Tyrode solution and in Tyrode solution containing 25 μg/ml ethanolic barks extract of Symplocos racemosa were performed. For invivo study histamine induced bronchospasm was performed using histamine chamber. 250 and 500 mg/kg of ethanolic bark extract of Symplocos racemosa were used and chlorpheniramine was used as reference control. The mean exposition time and percentage protection were calculated to assess the antiasthmatic potential of Symplocos racemosa. In isolated guinea pig ileum preparation, Symplocos racemosa relaxed the muscle against histamine and in histamine induced bronchospasm, both the doses of Symplocos racemosa bark extract significantly increased the mean exposition time and the percentage protection compared to control. From the result it was concluded that, Symplocos racemosa bark extract exhibits antiasthmatic activity.